Sex Hormones (Male): Analogs and Antagonists
نویسنده
چکیده
4 Synthetic Androgens 22 4.1 Current Drugs on the Market 22 4.2 Therapeutic Uses and Bioassays 22 4.3 Structure–Activity Relationships for Androgens 25 4.3.1 Early Modifications 25 4.3.2 Methylated Derivatives 25 4.3.3 Ester Derivatives 25 4.3.4 Halo Derivatives 26 4.3.5 Other Androgen Derivatives 26 4.3.6 Summary of Structure–Activity Relationships 27 4.4 Absorption, Distribution, and Metabolism 29 4.5 Toxicities 30
منابع مشابه
Effect of Withania somnifera (L.) Dunal on Sex Hormone and Gonadotropin Levels in Addicted Male Rats
Objective Opioid consumption has been widely increasing across the globe; however, it can cause adverse effects on the body. Morphine, an opioid, can reduce sex hormones and fertility. Withania somnifera (WS) is a traditional herb used to improve sexual activities. This study strives to investigate the effect of WS on sex hormones and gonadotropins in addicted male rats. MaterialsAndMethods In ...
متن کاملLeptin and sex hormones in psoriasis and correlation with disease severity
Background: Leptin, a 16-KDa peptide hormone secreted from theadipose tissue, plays an important role in the regulation of energyintake and expenditure and body weight regulation; furthermore,it has a regulatory function on the reproductive system. The aimof this study was to assess the relationship between serum leptinlevels and sex hormones in psoriatic patients and control groupand to determ...
متن کاملP-86: Protective Effect of Vitamin C and Royal Jelly on Sex Hormones on Phenylhydrazine Treated Adult Male Mice
Background: Phenylhydrazine (PHZ) is used to induce experimental anemia in animal models. On the other hand royal jelly is known as antioxidant compound. Therefore, here in present study we aimed to evaluate the protective effect of royal jelly on PHZ-induced damages in testicular tissue and compare its impact with vitamin C. Materials and Methods: Eighteen mature male mice were randomly divide...
متن کاملSex Differences and Role of Gonadal Hormones on Glutamate Level After Spinal Cord Injury in Rats: A Microdialysis Study
Introduction: Sex differences in outcomes of Spinal Cord Injury (SCI) suggest a sex-hormone-mediated effect on post-SCI pathological events, including glutamate excitotoxicity. This study aimed to investigate the importance of gonadal hormones on glutamate release subsequent to SCI in rats. Methods: After laminectomy at T8-T9, an electrolytic lesion was applied to the spinothalamic tracts of m...
متن کاملTHE SUBACUTE EFFECTS OF CADMIUM ON SEX HORMONES IN FEMALE RATS
Toxic effects of trace elements upon the hypothalamic- pituitarytesticular axis and sex hormones have been reported in recent years. It is generally considered that CdCl2 poisoning causes histopathological changes in the testicles of male rats. Little attention had been drawn to the possible toxic effects of CdCl2 on the ovary and female sex hormones. The purpose of the present study was t...
متن کامل